Seedorf speaks six languages fluently: Dutch, English, Italian, Portuguese, Spanish and Sranan Tongo. He was often seen as a spiritual, intelligent and articulate figure in football, and in a 2011 interview, Seedorf stated that he was studying to obtain a master’s degree in Business at the prestigious Bocconi University in Milan; because of this, he earned the nickname “il professore” (“the professor”) during his time playing at Milan. Seedorf is married to a Brazilian woman, Luviana Seedorf, with whom he owns a restaurant called Finger’s in Milan. They have four children. The relationship is rumored to have been ended around 2018, with Seedorf finding a new partner, Sophia Makramati, a Canadian citizen of Iranian descent and Muslim religious background. On 4 March 2022, Seedorf announced on Instagram that he had converted to Islam in Abu Dhabi.

Because of his strong connection with the country Suriname, where he was born, he is involved in many social development projects there. He built his own “Clarence Seedorf Stadium” in the district of Para in Suriname. In this stadium, the Para Juniors League of Suriname is being held and the teams of the Suri Profs & SV The Brothers play there regularly. With his Champions for Children Foundation, he supports projects for good causes in Suriname. For this, Suriname has honoured him to Commandor of the High-Order of the Yellow Star, and recently in 2011, he was invested as a Knight of the Order of Orange-Nassau (OON).

On 5 June 2009, Seedorf announced at a press conference after a meeting with Nelson Mandela that he had become the Nelson Mandela Foundation’s latest Legacy Champion. He joins Patrice Motsepe, Tokyo Sexwale, David Rockefeller, Peggy Dulany and Bill Clinton, who are also members of a select group of philanthropists who are helping to ensure that Mr. Mandela’s legacy lives on.

In 2012 and 2014, Seedorf took part in Soccer Aid, a charity match at Old Trafford with former professional players and celebrities. He played for “The Rest of the World” team against England. In 2014, he scored a hat-trick, where The Rest of the World won 4–2; they raised over £4 million in total.

Clarence’s nephew, Collin Seedorf, is also a professional footballer, and currently plays for Dutch club, FC Eindhoven.